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Posted: Saturday, December 23, 2017 10:41 AM


For nearly 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well:being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work e perform. In return, we'll help you build a career that you can feel passionate about.
Under the supervision of Manager or above, the Research Associate is responsible for performing and developing procedures for the assay of epithelial ion transport within non:regulated discovery and regulated (GMP) environments.

ESSENTIAL DUTIES AND RESPONSIBILITIES:
:Plan and perform ion transport studies in epithelial cultures derived from mammalian cell lines and human primary cells in accordance to FDA regulations, with general company goals and SOPs, applicable GMP regulations, timelines, and company productivity standards.
:Measure epithelial transport parameters (short circuit current, transepithelial potential, transepithelial electrical resistance (TEER)) using epithelial voltage clamps, data acquisition software, digitizers and Ussing chambers.
:Maintain sterility while measuring TEER and transepithelial potential over repeated measurements of the same epithelia using an epithelial voltage ohm meter such as the WPI EVOM2.
:Works with Quality Assurance to maintain GMP compliance of regulated assays and GMP facility.
:Coordinate cell culture inventory and production needs with cell culture staff to ensure sufficient epithelia are available.
:Prepare and maintain silver chloride agarose electrodes for use with epithelial voltage clamps; prepare electrode filling and storage solutions.
:Wash Ussing chambers; prepare Ussing chamber cleaning solutions.
:Maintain Ussing assay equipment (chambers, heater blocks, circulating water baths, air pumps, tubing, temperature sensors).
:Generate graphs of short circuit currents as a function of time, perform initial analysis of data.
:Perform QC check of data as needed.
:Maintain databases for trending of electrophysiology data.
:Implement experimental protocols.
:Complete daily documentation associated with essential duties and responsibilities.
:Communicate applicable experimental protocols to technicians; trains other technicians as needed.
:Prepare sterile and non:sterile general solutions and media used for electrophysiology.
:Solution preparation: calculate amounts to weigh, dilutions from concentrated solutions, adjust pH of solutions, prepare sterile solutions.
:Maintain test article inventory for assigned studies, coordinate with study directors.
:Perform routine inventory inspections to ensure electrophysiology reagents and supplies are current and at appropriate levels.
:Coordinate disposal of biohazardous chemicals in accordance to all applicable company SOPs and OSHA regulations.
:Perform standardization and internal calibration of balances in GMP facility as needed and document standardization and calibration accordingly.
:Develop ongoing working knowledge of company SOPs and federal regulations applicable to duties and responsibilities; complies to SOPs and regulations accordingly.
:Ensure laboratory notebook sheets, GMP logs specified in SOPs and other supporting documentation of electrophysiology assays are maintained in an organized, timely, and legible manner. Documentation is to be readily accessible for review as needed.
:Maintain electrophysiology equipment to ensure proper functionality; Notifies administration when repairs, replacement, or maintenance of equipment is required; documents maintenance accordingly.
:Be vaccinated for Hepatitis B virus or provide signed waiver.
:Attend and participate in meetings as required.
:Perform all other related duties as assigned.

QUALIFICATIONS:
:Education: Bachelors degree in Biology, Che

Source: https://www.tiptopjob.com/jobs/76186430_job.asp?source=backpage


• Location: Cleveland

• Post ID: 56072927 cleveland
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